Gene Regulation in Cancer

Head of Theme: Professor Glenn Marshall AM

It’s well known that altered gene regulation plays a major role in cancer. However, we know very little about the specific alterations that lead to the development of cancer in children. Our aim is to understand the molecular mechanisms behind the initiation and progression of childhood cancer, and with this information to develop more effective treatments and prevention strategies.

For the best chance of survival, it is vital that cancer in a child is detected as early as possible.

improved diagnosis

Our various approaches include studying factors in the pre- and perinatal environment that influence cancer initiation; using single cell profiling to decipher mechanisms of neuroblastoma tumorigenesis; elucidating and targeting histone modifications that alter gene transcription in childhood cancer; and developing small molecule inhibitors against novel onco-factors.