Children's Cancer Institute

Research theme

Research group

Cancer Epigenetic Biology and Therapeutics

Biography

Dr Fatima Valdes Mora (Fa) joined Children’s Cancer Institute in 2020 to establish a new research group, having been selected to take up one of our highly competitive Team Leader positions. In 2023, she was appointed Head of the Institute’s ‘Therapeutic Discovery’ Research Theme.

Prior to joining our Institute, Fa worked as a postdoctoral researcher at the Garvan Institute, where she established the Histone Variants Group. Fa has made significant contributions to our understanding of how genes are regulated in cancer, and key factors that can alter the expression of genes.

“I’ve been working for more than 10 years on cancer epigenetics, with a focus on one particular factor, a histone variant called H2A.Z” she explains. “I’ve shown that once we understand how a particular epigenetic factor works in cancer, we can then develop a specific drug to target it.”

Fa says cancer research has always been her passion, but with childhood cancer there is an extra level of motivation, particularly now she is a mother. Having previously worked on adult cancers such as prostate and breast cancer, she is now expanding her focus to cancers such as DIPG, the most aggressive brain tumour in children. “In adult cancer, many genetic mutations are known to be drivers. However, in childhood cancer, the mutation rate is quite low and epigenetics appears to play a more significant role.”

As well as investigating epigenetic factors that drive childhood cancer with a view to developing epigenetic therapies, Fa is also keen to develop new technologies that enable epigenetics to be interrogated in more depth. She is also researching the tumour microenvironment – the non-cancerous cells around tumours that change through epigenetics to help the cancer grow and spread. “I’m trying to understand the whole picture. To have effective treatment, you need to target both aspects: the cancer cells and the tumour microenvironment.”

Fa’s research has been published in high quality journals such as Trends in Genetics, Cell Reports, Journal of Clinical Investigation, Nature Communications, Genome Research and EMBO Journal. Fa is a Conjoint Senior Lecturer in the Faculty of Medicine at UNSW Sydney and the Postgraduate Coordinator for UNSW Centre for Childhood Cancer Research.